Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris.

@article{Scharf2012AnnexinAB,
  title={Annexin A2 binds to endosomes following organelle destabilization by particulate wear debris.},
  author={Brian Scharf and Cristina C. Clement and Xiao Xuan Wu and Kateryna S. Morozova and Diego Zanolini and Antonia Follenzi and Jorge N. Larocca and Kalle Lev{\'o}n and Fayyaz S. Sutterwala and Jacob H. Rand and Neil J. Cobelli and Ed Purdue and Katherine A Hajjar and Laura Santambrogio},
  journal={Nature communications},
  year={2012},
  volume={3},
  pages={
          755
        }
}
Endosomal functions are contingent on the integrity of the organelle-limiting membrane, whose disruption induces inflammation and cell death. Here we show that phagocytosis of ultrahigh molecular weight polyethylene particles induces damage to the endosomal-limiting membrane and results in the leakage of cathepsins into the cytosol and NLRP3-inflammasome activation. Annexin A2 recruitment to damaged organelles is shown by two-dimensional DIGE protein profiling, endosomal fractionation, confocal… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

Annexin A2 Deficiency Exacerbates Neuroinflammation and Long-Term Neurological Deficits after Traumatic Brain Injury in Mice

VIEW 2 EXCERPTS
CITES BACKGROUND

The annexin A2 system and angiogenesis

VIEW 1 EXCERPT
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Mitochondria: Sovereign of inflammation?

sovereign of inflammation? Eur

  • Tschopp, J. Mitochondria
  • J. Immunol. 41, 1196–1202
  • 2011

its role in transport of mannose 6-phosphate receptors

  • Rodriguez-Gabin, A. G. et al. Interaction of Rab31, OCRL-1 in oligodendrocytes
  • J. Neurosci. Res. 88, 589–604
  • 2010

guardians of cytosolic sanctity

  • M. Lamkanfi, Dixit, V. M. Inflammasomes
  • Immunol. Rev. 227, 95–105
  • 2009