Annexin A1 regulates intestinal mucosal injury, inflammation, and repair.

  title={Annexin A1 regulates intestinal mucosal injury, inflammation, and repair.},
  author={Brian A. Babbin and Mike Georg Laukoetter and Porfirio Nava and Stefan Koch and Winston Y. Lee and Christopher T. Capaldo and Eric Peatman and Eric A. Severson and Roderick John Flower and Mauro Perretti and Charles A Parkos and Asma Nusrat},
  journal={Journal of immunology},
  volume={181 7},
During mucosal inflammation, a complex array of proinflammatory and protective mechanisms regulates inflammation and severity of injury. Secretion of anti-inflammatory mediators is a mechanism that is critical in controlling inflammatory responses and promoting epithelial restitution and barrier recovery. AnxA1 is a potent anti-inflammatory protein that has been implicated to play a critical immune regulatory role in models of inflammation. Although AnxA1 has been shown to be secreted in… CONTINUE READING


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