Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles.

@article{Dalli2008Annexin1M,
  title={Annexin 1 mediates the rapid anti-inflammatory effects of neutrophil-derived microparticles.},
  author={Jesmond Dalli and Lucy V Norling and Derek W. Renshaw and Dianne Cooper and Kit-yi Leung and Mauro Perretti},
  journal={Blood},
  year={2008},
  volume={112 6},
  pages={2512-9}
}
Polymorphonuclear leukocyte (PMN)-derived microparticles display inhibitory properties on target cells as assessed in vitro; since PMNs contain abundant amounts of the endogenous anti-inflammatory protein annexin 1 (AnxA1), we tested here whether biologically active AnxA1 could be present in PMN-derived microparticles. PMN adhesion to human umbilical vein endothelial cell (HUVEC) monolayers led to the generation of microparticles that contained AnxA1, as detected by Western blotting, flow… CONTINUE READING
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