Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation.

  title={Annexin-1-deficient dendritic cells acquire a mature phenotype during differentiation.},
  author={Anthony Huggins and Nikolaos Paschalidis and Roderick John Flower and Mauro Perretti and Fulvio D'Acquisto},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={23 4},
Dendritic cells play a key role in the adaptive immune system by influencing T-cell differentiation. Annexin-1 (Anx-A1) has recently been shown to modulate the adaptive immune response by regulating T-cell activation and differentiation. Here we investigated the role of endogenous Anx-A1 in dendritic cells as major cellular counterpart of T-cell-driven immune response. We found that Anx-A1(-/-) bone marrow-derived dendritic cells show an increased number of CD11c(+) cells expressing high levels… CONTINUE READING