Annexin 1 and the biology of the neutrophil

@article{Perretti2004Annexin1A,
  title={Annexin 1 and the biology of the neutrophil},
  author={Mauro Perretti and Roderick John Flower},
  journal={Journal of Leukocyte Biology},
  year={2004},
  volume={76}
}
This overview will focus on one aspect of neutrophil biology, which is the selective activation of the annexin 1 system in relation to the process of cell extravasation. Besides the current view about the biochemistry of annexin 1 and annexin 1 receptor(s) up‐regulation within the microenvironment of the adherent neutrophils, we will also comment on the final result achieved by activation of the system, which is inhibition of neutrophil recruitment. In view of the historical link between… 
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Annexin 1 Cleavage in Activated Neutrophils
TLDR
A cleavage assay using tagged annexin 1 is developed and marked activity in the membrane fraction of activated neutrophils is observed, identifying proteinase 3 as the main enzyme responsible for this cleavage in the N terminus region of the protein, at least in the context of neutrophil activation.
An overview of the effects of annexin 1 on cells involved in the inflammatory process.
TLDR
It is proposed that a more systematic analysis of ANXA1 physio-pharmacology in cells involved in the host inflammatory reaction could aid in the design of novel anti-inflammatory therapeutics based on this endogenous mediator.
Advancements of Annexin A1 in inflammation and tumorigenesis
TLDR
This summary will be very important for further investigation of the pathophysiological role of Annexin A1 and for the development of novel therapeutics of inflammatory and cancer based on targeting AnnexIn A1 protein.
Expression and functions of annexins in the kidney.
TLDR
This review article summarizes current knowledge about the locations and possible functions of annexin family members in the kidney and focuses on individual members with documented and/or proposed physiological relevance for renal development, structure, and functions.
Functional and ultrastructural analysis of annexin A1 and its receptor in extravasating neutrophils during acute inflammation.
TLDR
In vivo support is provided to the hypothesis that endogenous AnxA1 is an essential effector of endogenous anti-inflammation and an ultrastructural indication that this mediator interacts with Fpr2 in murine neutrophils is provided.
Annexin A1 and glucocorticoids as effectors of the resolution of inflammation
TLDR
A model in which glucocorticoids regulate the expression and function of annexin A1 in opposing ways in innate and adaptive immune cells to mediate the resolution of inflammation is proposed.
Annexin A1 and annexin A5 in cardiovascular disease
TLDR
This study involves two members of the annexin family of proteins and their relationship to cardiovascular disease and the inhibiting effect of annexin A5 on clearing away dead cells and the enhancing effect on ‘arteriosclerosis’.
Modulation of equine neutrophil adherence and migration by the annexin-1 derived N-terminal peptide, Ac2-26.
Anti-adhesive proteins and resolution of neutrophil-mediated inflammation.
The restorative role of annexin A1 at the blood–brain barrier
TLDR
An overview of the role of annexin A1 in the brain is provided, with a particular emphasis on its functions in the endothelium of the blood–brain barrier, and the protective actions the molecule may exert in neuroinflammatory, neurovascular and metabolic disease.
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TLDR
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