Ankyrin and spectrin associate with voltage-dependent sodium channels in brain

@article{Srinivasan1988AnkyrinAS,
  title={Ankyrin and spectrin associate with voltage-dependent sodium channels in brain},
  author={Yogambal Srinivasan and Lawrence Elmer and Jonathan Davis and Vann Bennett and Kimon J. Angelides},
  journal={Nature},
  year={1988},
  volume={333},
  pages={177-180}
}
The segregation of voltage-dependent sodium channels to specialized regions of the neuron is crucial for propagation of an action potential1–5. Studies of their lateral mobility indicate that sodium channels are freely mobile on the neuronal cell body but are immobile at the axon hillock, presynaptic terminal and at focal points along the axon6. To elucidate the mechanisms that regulate sodium channel topography and mobility, we searched for specific proteins from the brain that associate with… CONTINUE READING

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