Ankylosis in ankylosing spondylitis: current concepts

@article{Haroon2015AnkylosisIA,
  title={Ankylosis in ankylosing spondylitis: current concepts},
  author={N. Haroon},
  journal={Clinical Rheumatology},
  year={2015},
  volume={34},
  pages={1003-1007}
}
  • N. Haroon
  • Published 2015
  • Medicine
  • Clinical Rheumatology
Ankylosing spondylitis (AS) is the most common form of spondyloarthritis and is characterized by both inflammation and new bone formation. Despite many years of arduous efforts, we still do not clearly understand the pathogenesis of AS. The mechanisms behind new bone formation have been especially challenging to decipher due to the difficulty in obtaining tissue from spinal joints. The link between inflammation and bone formation looks obvious, but how inflammation drives spinal fusion is not… Expand
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References

SHOWING 1-10 OF 62 REFERENCES
NSAIDs and radiographic progression in ankylosing spondylitis Bagging big game with small arms?
TLDR
Supportive evidence is provided that NSAIDs may slow the progression of bony change of the spine in AS. Expand
Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis.
TLDR
It is reported that this process partially recapitulates embryonic endochondral bone formation in a spontaneous model of arthritis in DBA/1 mice, suggesting that BMP signaling is an attractive therapeutic target for interfering with structural changes in spondyloarthropathy either as an alternative or complementary approach to current antiinflammatory treatments. Expand
Association of Bone Morphogenetic Proteins with Spinal Fusion in Ankylosing Spondylitis
TLDR
Rising levels of BMP in AS patients with spinal fusion and the positive correlation between BMP and spinal radiograph scores indicate that BMP may play a role in the process of spinal ankylosis. Expand
The natural disease course of ankylosing spondylitis.
TLDR
It is suggested that a predictable pattern of ankylosing spondylitis emerges within the first 10 years of the disease. Expand
Classification of inflammatory arthritis by enthesitis
TLDR
It is proposed that the synovitis of spondyloarthropathy is secondary to liberation of proinflammatory mediators from the enthesis, whereas the synvitis of rheumatoid arthritis is primary. Expand
Radiographic progression in patients with ankylosing spondylitis after 2 years of treatment with the tumour necrosis factor α antibody infliximab
TLDR
Patients with AS treated with infliximab had less radiographic progression after 2 years, and infliximab may decelerate radiography progression in such patients with prevalent radiographic damage, which is prone to develop more damage over time. Expand
Evidence that Dkk-1 is dysfunctional in ankylosing spondylitis.
TLDR
The findings indicate that in patients with AS, circulating bone formation-promoting factors functionally prevail, which can be at least partially attributed to decreased Dkk-1-mediated inhibition. Expand
High level of functional dickkopf-1 predicts protection from syndesmophyte formation in patients with ankylosing spondylitis
TLDR
AS patients with no syndesmophyte formation show significantly higher functional Dkk1 levels suggesting that blunted Wnt signalling suppresses new bone formation and consequently syndsmophyte growth and spinal ankylosis. Expand
The impact of tumor necrosis factor α inhibitors on radiographic progression in ankylosing spondylitis.
TLDR
Treatment with TNFα inhibitors appears to reduce radiographic progression in patients with ankylosing spondylitis, especially with early initiation and with longer duration of followup, and the protective effect of TNF α inhibitors was stronger after propensity score matching. Expand
Proof of concept: enthesitis and new bone formation in spondyloarthritis are driven by mechanical strain and stromal cells
TLDR
Findings provide a formal proof of the concept that mechanical strain drives both entheseal inflammation and new bone formation in SpA. Expand
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