Ankylosing spondylitis susceptibility and severity--contribution of TNF gene promoter polymorphisms at positions -238 and -308.

@article{Sousa2009AnkylosingSS,
  title={Ankylosing spondylitis susceptibility and severity--contribution of TNF gene promoter polymorphisms at positions -238 and -308.},
  author={Elsa Sousa and Joana Caetano-Lopes and Patr{\'i}cia Pinto and Fernando Silvio Cavalcante Pimentel and Jos{\'e} M{\'a}rio Meira Teles and Helena Canh{\~a}o and Ana L{\'u}cia Chalhoub Chedi{\'a}c Rodrigues and Catarina Resende and Ana Filipa Mour{\~a}o and C{\'e}lia Maria Ribeiro and Teresa Laura Pinto and Carlos Miranda Rosa and Jos{\'e} Alberto Pereira da Silva and Jaime Branco and F. Ventura and M{\'a}rio Fernando Oliveira Viana de Queiroz and Jo{\~a}o Eurico Fonseca},
  journal={Annals of the New York Academy of Sciences},
  year={2009},
  volume={1173},
  pages={581-8}
}
Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on AS susceptibility and prognosis. SNPs were determined by restriction fragment length polymorphisms… CONTINUE READING
8 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…