Ankylosing spondylitis is linked to Klebsiella—the evidence

@article{Rashid2006AnkylosingSI,
  title={Ankylosing spondylitis is linked to Klebsiella—the evidence},
  author={Taha M. Rashid and Alan Ebringer},
  journal={Clinical Rheumatology},
  year={2006},
  volume={26},
  pages={858-864}
}
Ankylosing spondylitis (AS) is a chronic inflammatory spinal and large-joint arthritic and potentially disabling condition, mainly affecting males of young age groups. Extensive literature based on the results of various genetic, microbiological, molecular and immunological studies carried out by independent research groups suggests that Klebsiella pneumoniae is the main microbial agent being implicated as a triggering and/or perpetuating factor in the etiopathogenesis of AS. Novel diagnostic… 
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TLDR
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Genetics and genomics of ankylosing spondylitis
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References

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Ankylosing spondylitis is caused by Klebsiella. Evidence from immunogenetic, microbiologic, and serologic studies.
  • A. Ebringer
  • Medicine, Biology
    Rheumatic diseases clinics of North America
  • 1992
TLDR
It is suggested that therapeutic trials should be set up with the aim of eliminating Klebsiella microbes, in an endeavor to test the validity of this theory.
Ankylosing Spondylitis, HLA-B27 and Klebsiella - An Overview: Proposal for Early Diagnosis and Treatment
TLDR
It is suggested that identifying and treating patients with Klebsiella reactive arthritis/pre-AS could involve the use of anti- KlebsIElla measures, such as antibiotics and low starch diet together with immunosuppressive drugs in an endeavour to prevent the irreversible sequelae of established AS.
Faecal flora in spondyloarthropathy.
TLDR
There was no increased isolation rate of Klebsiella or other proposed arthritogenic organism in those with spondyloarthropathy and its presence was not related to disease activity, the erythrocyte sedimentation rate or C-reactive protein.
Genetic susceptibility to ankylosing spondylitis.
TLDR
Methods for genetic investigation of ankylosing spondylitis are described, the status of current research in this exciting area is summarized, and there is compelling evidence that non-B27 genes, both within and outwith the major histocompatability complex, are involved in disease aetiology.
Ankylosing spondylitis: klebsiella and HL-A B27.
A search for the presence of Klebsiella-Enterobacter spp. and Yersinia enterocolitica in urine and faeces of 63 patients with ankylosing spondylitis was conducted because these microorganisms have
No conclusive evidence of an epidemiological relation between Klebsiella and ankylosing spondylitis.
TLDR
In the patient group no temporal relation could be found between activity of the disease and the presence of Klebsiella in the intestinal tract and in a dynamic study changes in Klebsies quantity over a period of 3 months were compared with changes in disease activity over the same period.
Klebsiella pneumoniae and acute anterior uveitis in ankylosing spondylitis.
TLDR
Evidence of a cross-reactivity among three Gramnegative micro-organisms-Enterobacter aerogenes, Klebsiella pneumoniae, and Yersinia entercolitica-and HLA B27 positive lymphocytes is reported and it is found that Kl pneumoniae was found more frequently in AS patients with active disease than in controls or patients with inactive disease.
Frequency of faecal Klebsiella aerogenes in patients with ankylosing spondylitis and controls with respect to individual features of the disease.
TLDR
The results suggest that K. aerogenes may have an aetiological role in the development of non-granulomatous anterior uveitis and peripheral arthritis in patients with ankylosing spondylitis but do not lend support to this organism having such a role inThe spinal disease itself.
Antibodies to Klebsiella and Proteus microorganisms in ankylosing spondylitis and rheumatoid arthritis patients measured by ELISA.
Antibodies to Klebsiella oxytoca and Proteus mirabilis in 21 active ankylosing spondylitis (AS), 13 active rheumatoid arthritis (RA), 19 inactive RA patients and 18 healthy controls were measured
Ileocolonoscopic findings in seronegative spondylarthropathies.
TLDR
Some of the patients with seronegative spondylarthropathies suffer from a subclinical form of Crohn's disease of which the joint symptoms are the unique clinical manifestation, support for this hypothesis was provided by the results of a repeat ileocolonoscopy, disclosing a strong association between the presence of gut inflammation on biopsy and the persistence of joint inflammation.
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