Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts.

@article{Fei2011Ankrd26GD,
  title={Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts.},
  author={Zhaoliang Fei and Tapan Kumar Bera and Xiufen Liu and Laiman Xiang and Ira Pastan},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 31},
  pages={
          27761-8
        }
}
We previously reported that partial disruption of the Ankrd26 gene in mice leads to hyperphagia and leptin-resistant obesity. To determine whether the Ankrd26 mutation can affect the development of adipocytes, we studied mouse embryo fibroblasts (MEFs) from the mutant mice. We found that Ankrd26(-/-) MEFs have a higher rate of spontaneous adipogenesis than normal MEFs and that adipocyte formation is greatly increased when the cells are induced with troglitazone alone or with a mixture of… CONTINUE READING
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