Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro

@article{Frey1988AnisomycinAI,
  title={Anisomycin, an inhibitor of protein synthesis, blocks late phases of LTP phenomena in the hippocampal CA1 region in vitro},
  author={Uwe Frey and Manfred Krug and Klaus G. Reymann and Hansju¨rgen Matthies},
  journal={Brain Research},
  year={1988},
  volume={452},
  pages={57-65}
}
Long-term potentiation (LTP) with its extremely long duration has been frequently regarded as an elementary mechanism of information storage in the nervous system or at least as a suitable model for the study of mechanisms underlying functional plasticity and processes of learning and memory formation. Considering the necessity of an increased protein synthesis for memory consolidation and for the maintenance of LTP in granular synapses in vivo it was of interest to determine whether the LTP of… Expand
Effects of anisomycin on LTP in the hippocampal CA1: long-term analysis using optical recording
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Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons.
TLDR
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Protein synthesis-dependent formation of protein kinase Mzeta in long- term potentiation
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TLDR
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Influence of actinomycin D, a RNA synthesis inhibitor, on long‐term potentiation in rat hippocampal neurons in vivo and in vitro.
TLDR
The requirement for transcription during LTP may have a critical time window since actinomycin D was only effective in influencing the maintenance of LTP when applied before tetanization, suggesting different mechanisms for the two forms of potentiation. Expand
Genetic Demonstration of a Role for PKA in the Late Phase of LTP and in Hippocampus-Based Long-Term Memory
TLDR
In transgenic mice that express R(AB), an inhibitory form of the regulatory subunit of PKA, only in the hippocampus and other forebrain regions, hippocampal PKA activity was reduced, and L-LTP was significantly decreased in area CA1, without affecting basal synaptic transmission or the early phase of LTP. Expand
Re-evaluation of the hypothesis that LTP has two temporal phases and that the late phase is protein synthesis- dependent
TLDR
The results suggest that the temporal distinction of LTP into Eand L-LTP is a false dichotomy and the rate of protein degradation may explain whether PSIs would, or would not, have an effect on LTP stabilization. Expand
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TLDR
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