Anionic activators for differential sensing with cell-penetrating peptides.

@article{Montenegro2011AnionicAF,
  title={Anionic activators for differential sensing with cell-penetrating peptides.},
  author={Javier Montenegro and Stefan Matile},
  journal={Chemistry, an Asian journal},
  year={2011},
  volume={6 2},
  pages={681-9}
}
The design, synthesis, and evaluation of small peptides with one to three negative charges and one to three hydrazides as key components of membrane-based synthetic sensing systems are reported. Their spontaneous reaction with hydrophobic aldehydes or ketones gives rapid access to small collections of amphiphilic anions. These anionic amphiphiles can… CONTINUE READING