Anion permeation in an apical membrane chloride channel of a secretory epithelial cell

@article{Halm1992AnionPI,
  title={Anion permeation in an apical membrane chloride channel of a secretory epithelial cell},
  author={Dan R. Halm and Raymond A Frizzell},
  journal={The Journal of General Physiology},
  year={1992},
  volume={99},
  pages={339 - 366}
}
Single channel currents though apical membrane Cl channels of the secretory epithelial cell line T84 were measured to determine the anionic selectivity and concentration dependence of permeation. The current-voltage relation was rectified with single channel conductance increasing at positive potentials. At 0 mV the single channel conductance was 41 +/- 2 pS. Permeability, determined from reversal potentials, was optimal for anions with diameters between 0.4 and 0.5 nm. Anions of larger… CONTINUE READING

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