Anion-induced water flux as drug release mechanism through cationic Eudragit RS 30D film coatings

@article{Wagner2005AnioninducedWF,
  title={Anion-induced water flux as drug release mechanism through cationic Eudragit RS 30D film coatings},
  author={K. G. Wagner and Ronny Gruetzmann},
  journal={The AAPS Journal},
  year={2005},
  volume={7},
  pages={E668-E677}
}
The objective of this study was to investigate the anion-controlled drug release mechanism through the cationic coating polymer Eudragit RS 30 D as a function of the anion attraction toward the polymer’s quarternary ammonium group (QAG), anion valence, and film composition. The mechanism was investigated by dissolution testing, determination of chloride ion exchange using ion chromatography, plasticizer leaching by means of differential scanning calorimetry, and water uptake by Karl Fischer… CONTINUE READING

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