Anion exchange membrane adsorbers for flow-through polishing steps: Part II. Virus, host cell protein, DNA clearance, and antibody recovery.

@article{Weaver2013AnionEM,
  title={Anion exchange membrane adsorbers for flow-through polishing steps: Part II. Virus, host cell protein, DNA clearance, and antibody recovery.},
  author={Justin R. Weaver and Scott M Husson and Louise B Murphy and Sumith Ranil Wickramasinghe},
  journal={Biotechnology and bioengineering},
  year={2013},
  volume={110 2},
  pages={
          500-10
        }
}
Anion exchange membrane adsorbers are used for contaminant removal in flow-through polishing steps in the manufacture of biopharmaceuticals. This contribution describes the clearance of minute virus of mice, DNA, and host cell proteins by three commercially available anion-exchange membranes: Sartobind Q, Mustang Q, and ChromaSorb. The Sartobind Q and Mustang Q products contain quaternary amine ligands; whereas, ChromaSorb contains primary amine based ligands. Performance was evaluated over a… CONTINUE READING
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Review: Implementation of advanced technologies in commercial monoclonal antibody production

  • JX Zhou, X Tressel Yang, T. Seewoester
  • Biotechnol J 3(9–10):1185–1200.
  • 2008
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