Anion channel blockers inhibit lysosomal enzyme secretion from human neutrophils without affecting generation of superoxide anion.

Abstract

The role of permeant anions in lysosomal enzyme secretion from human neutrophils was investigated by means of anion-channel-blocking agents: 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), 4-acetamido-4'-isothiocyanostilbene-2,2'-disulfonic acid (SITS), and pyridoxal phosphate. Lysosomal enzyme release from cytochalasin B-treated human neutrophils… (More)

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@article{Korchak1980AnionCB, title={Anion channel blockers inhibit lysosomal enzyme secretion from human neutrophils without affecting generation of superoxide anion.}, author={Helen M. Korchak and B A Eisenstat and Sylvia T. Hoffstein and Philip B. Dunham and Gaia Weissmann}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1980}, volume={77 5}, pages={2721-5} }