Anion- and proton-dependent gating of ClC-4 anion/proton transporter under uncoupling conditions.

@article{Orhan2011AnionAP,
  title={Anion- and proton-dependent gating of ClC-4 anion/proton transporter under uncoupling conditions.},
  author={G{\"o}kce Orhan and Christoph Fahlke and Alexi Kirilov Alekov},
  journal={Biophysical journal},
  year={2011},
  volume={100 5},
  pages={1233-41}
}
ClC-4 is a secondary active transporter that exchanges Cl(-) ions and H(+) with a 2:1 stoichiometry. In external SCN(-), ClC-4 becomes uncoupled and transports anions with high unitary transport rate. Upon voltage steps, the number of active transporters varies in a time-dependent manner, resembling voltage-dependent gating of ion channels. We here investigated modification of the voltage dependence of uncoupled ClC-4 by protons and anions to quantify association of substrates with the… CONTINUE READING

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