Anion-Dependent Stimulation of CYP3A4 Monooxygenase.


We co-crystallized human cytochrome P450 3A4 (CYP3A4) with progesterone (PRG) under two different conditions, but the resulting complexes contained only one PRG molecule bound to the previously identified peripheral site. A novel feature in one of our structures is a citrate ion, originating from the crystallization solution. The citrate-binding site is… (More)
DOI: 10.1021/acs.biochem.5b00510


Cite this paper

@article{Sevrioukova2015AnionDependentSO, title={Anion-Dependent Stimulation of CYP3A4 Monooxygenase.}, author={Irina F Sevrioukova and Thomas L Poulos}, journal={Biochemistry}, year={2015}, volume={54 26}, pages={4083-96} }