Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion

@article{Dragan2000AnimalSA,
  title={Animal studies addressing the carcinogenicity of TCDD (or related compounds) with an emphasis on tumour promotion},
  author={Yvonne P. Dragan and Dieter Schrenk},
  journal={Food Additives \& Contaminants},
  year={2000},
  volume={17},
  pages={289 - 302}
}
Dioxin and certain structurally related compounds increase the incidence of liver neoplasms in rodents upon chronic bioassay. Short-term studies indicate the lack of direct DNA-damaging effects including covalent binding to DNA; however, secondary mechanisms may be important in the observed carcinogenicity as these chemicals affect a number of pathways necessary for maintenance of normal growth control and differentiation status. Studies with TCDD in the mouse skin support a lack of initiating… 

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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