Animal models with pathological mineralization phenotypes.

  title={Animal models with pathological mineralization phenotypes.},
  author={Uwe Kornak},
  journal={Joint, bone, spine : revue du rhumatisme},
  volume={78 6},
Extracellular matrix mineralization is important for mechanical stability of the skeleton and for calcium and phosphate storage. Professional mineral-disposing cell types are hypertrophic chondrocytes, odontoblasts, ameloblasts and osteoblasts. Since ectopic mineralization causes tissue dysfunction mineralization inhibitors and promoting factors have to be kept in close balance. The most prominent inhibitors are fetuin-A, matrix-Gla-protein (MGP), SIGBLING proteins and pyrophosphate. In spite… CONTINUE READING