Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia

@article{Castner2003AnimalMO,
  title={Animal models of working memory: insights for targeting cognitive dysfunction in schizophrenia},
  author={S. Castner and P. Goldman-Rakic and Graham V. Williams},
  journal={Psychopharmacology},
  year={2003},
  volume={174},
  pages={111-125}
}
Background and rationaleWorking memory performance is considered to be a core deficit in schizophrenia and the best predictor of social reintegration and propensity for relapse. This cardinal cognitive process is critical for human reasoning and judgment and depends upon the integrity of prefrontal function. Prefrontal dysfunction in schizophrenia has been linked to altered dopaminergic and glutamatergic transmission. However, to date, antipsychotics provide no substantial relief from the… Expand
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