Animal models of the serotonin syndrome: A systematic review

  title={Animal models of the serotonin syndrome: A systematic review},
  author={Robert Haberzettl and Bettina Bert and Heidrun Fink and Meredith A. Fox},
  journal={Behavioural Brain Research},
The serotonin syndrome (SS) is a potentially life-threatening disorder in humans which is induced by ingestion of an overdose or by combination of two or more serotonin (5-HT)-enhancing drugs. In animals, acute administration of direct and indirect 5-HT agonists also leads to a set of behavioral and autonomic responses. In the current review, we provide an overview of the existing versions of the animal model of the SS. With a focus on studies in rats and mice, we analyze the frequency of… CONTINUE READING
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