Animal models of suicide-trait-related behaviors.

  title={Animal models of suicide-trait-related behaviors.},
  author={Oz Malkesman and Daniel S. Pine and Tyson R Tragon and Daniel R. Austin and Ioline D. Henter and Guang Chen and Husseini K. Manji},
  journal={Trends in pharmacological sciences},
  volume={30 4},
Although antidepressants are moderately effective in treating major depressive disorder (MDD), concerns have arisen that selective serotonin-reuptake inhibitors (SSRIs) are associated with suicidal thinking and behavior, especially in children, adolescents and young adults. Almost no experimental research in model systems has considered the mechanisms by which SSRIs might be associated with this potential side effect in some susceptible individuals. Suicide is a complex behavior and impossible… CONTINUE READING
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