Animal models of sepsis and shock: a review and lessons learned.

@article{Deitch1998AnimalMO,
  title={Animal models of sepsis and shock: a review and lessons learned.},
  author={Edwin A. Deitch},
  journal={Shock},
  year={1998},
  volume={9 1},
  pages={1-11}
}
Over the past decade, the biotechnology/pharmaceutical industry has been diligently working on the development of immunomodulatory agents for the treatment of shock and sepsis, and the literature is rife with descriptions of novel and innovative molecules that promise to become the panacea for these conditions. Unfortunately, despite promising preclinical evidence, dozens of these new agents have failed to demonstrate clinical efficacy in controlled, randomized clinical trials, abandoning the… CONTINUE READING
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