Animal models of psoriasis and pustular psoriasis

  title={Animal models of psoriasis and pustular psoriasis},
  author={Hitoshi Mizutani and Keiichi Yamanaka and Hiroshi Konishi and Takaaki Murakami},
  journal={Archives of Dermatological Research},
Investigation of psoriasis and pustular psoriasis is presently hampered by the lack of appropriate animal models. So far, more than ten models have been developed in mice by spontaneous gene mutations and by gene manipulation. However, none of them has satisfactorily reproduced the clinicopathological and immunopathological phenotypes of these diseases. Xenotransplantation techniques have been used for designing models of psoriasis vulgaris, in which CD4+ T cells have been shown to play an… CONTINUE READING


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Animal models of psoriasis - what can we learn from them?

The Journal of investigative dermatology • 1999