• Corpus ID: 1219432

Animal models of nociception.

  title={Animal models of nociception.},
  author={Daniel le Bars and Manuela Gozariu and Samuel W. Cadden},
  journal={Pharmacological reviews},
  volume={53 4},
The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them. Philosophically, there is the problem that pain cannot be monitored directly in animals but can only be estimated by examining their responses to nociceptive stimuli; however, such responses do not necessarily mean that there is a concomitant sensation. The… 

Animal Models of Nociception and Pain

Research on the neurobiological bases of nociception and pain and related investigations of potential therapies require great reliance on animal models, and models intended to address pain must be validated for this purpose.

The application of conditioning paradigms in the measurement of pain.

  • Jun-Xu Li
  • Psychology
    European journal of pharmacology
  • 2013

Tests and models of nociception and pain in rodents

Operant nociception in nonhuman primates

Remote Controlled Nociceptive Threshold Testing Systems in Large Animals

  • P. Taylor
  • Biology
    Animals : an open access journal from MDPI
  • 2020
Remote controlled thermal and mechanical NT testing systems were developed to allow free movement during testing and were evaluated in cats, dogs, sheep, horses and camels and appeared to be a viable refinement for pain research.

Common animal models for spasticity and pain.

  • M. Eaton
  • Biology, Psychology
    Journal of rehabilitation research and development
  • 2003
The few extant models of spasticity, nerve injury, and central injury models of pain are reviewed, and their features and use are described.

Animal Models of Pain and Ethics of Animal Experimentation

Animal studies have advanced the understanding of the anatomical, biochemical, and physiological mechanisms of pain by applying various nociceptive stimuli to specific organs of the body, creating models that reflect the physical, cognitive, and psychosocial dimensions of clinical pain conditions.

Modelos animales de dolor. Una visión crítica

To determine the adaptation mechanisms that are initiated in order to offset the induced defects and their impact on nociception mechanisms, the advance of automated tests for the assessment of nOCiception is driven.


There are numerous aspects of nociception studies, describing these tests as a simple matter of first accounting for the nature of the stimulus and then describing the behavioural parameters that are measured, but assessments vary with the scale used, while also the scales can be very subjective.

A Novel Behavioral Fish Model of Nociception for Testing Analgesics

Zebrafish (Danio rerio) is proposed as a novel short-term behavioral model of nociception and its sensitivity and robustness are analyzed to suggest that a change in behavioral responses of zebrafish to acetic acid is a reasonable model to test analgesics.



Avoiding fallacies in nociceptive measurements

Stress-induced analgesia: adaptive pain suppression.

The examination of the neurotransmitter and neuropeptide systems has revealed that they are affected by the same manipulations that induce SIA, and these amines and peptides play an integral role in learning, motivation, and performance.

Hyperalgesia Induced by Emotional Stress in the Rat: An Experimental Animal Model of Human Anxiogenic Hyperalgesia

  • C. VidalJ. Jacob
  • Biology, Psychology
    Annals of the New York Academy of Sciences
  • 1986
The biological significance of environmental events would appear to be a critical factor in the triggering of pain modulatory systems, and is of relevance when one compares the nature of the environmental factors that lead to analgesia with those that produce hyperalgesia.

Methodological refinements to the mouse paw formalin test. An animal model of tonic pain.

Evolutionary and comparative aspects of nociception

The relevance of animal neuropathy models for chronic pain in humans

There are currently more than 30 animal models for neuropathic pain. These models are characterized by specific combinations of anomalous nocifensive behavior which suggest the presence of

Biological rhythms in pain and in the effects of opioid analgesics.

For Debate: Reflex responses do not necessarily signify pain

Can a fetus feel pain? This question is appropriate, as medical interventions during pregnancy,1 fetal surgery,2 and possibly termination of pregnancy expose the fetus to noxious stimuli. To answer


  • L. C. Miller
  • Medicine
    Annals of the New York Academy of Sciences
  • 1948
The literature on methods used up to that time to evaluatc pain intensity and the analgesic effects of drugs are reviewed, setting up four criteria which the ideal method should meet in yielding quantitative data on the extent to which an analgesic obtunds pain.

A behavioural model for the study of facial nociception and the effects of descending modulatory systems in the rat