• Corpus ID: 1219432

Animal models of nociception.

@article{leBars2001AnimalMO,
  title={Animal models of nociception.},
  author={Daniel le Bars and Manuela Gozariu and Samuel W. Cadden},
  journal={Pharmacological reviews},
  year={2001},
  volume={53 4},
  pages={
          597-652
        }
}
The study of pain in awake animals raises ethical, philosophical, and technical problems. We review the ethical standards for studying pain in animals and emphasize that there are scientific as well as moral reasons for keeping to them. Philosophically, there is the problem that pain cannot be monitored directly in animals but can only be estimated by examining their responses to nociceptive stimuli; however, such responses do not necessarily mean that there is a concomitant sensation. The… 

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References

SHOWING 1-10 OF 765 REFERENCES

Avoiding fallacies in nociceptive measurements

Stress-induced analgesia: adaptive pain suppression.

TLDR
The examination of the neurotransmitter and neuropeptide systems has revealed that they are affected by the same manipulations that induce SIA, and these amines and peptides play an integral role in learning, motivation, and performance.

Hyperalgesia Induced by Emotional Stress in the Rat: An Experimental Animal Model of Human Anxiogenic Hyperalgesia

  • C. VidalJ. Jacob
  • Biology, Psychology
    Annals of the New York Academy of Sciences
  • 1986
TLDR
The biological significance of environmental events would appear to be a critical factor in the triggering of pain modulatory systems, and is of relevance when one compares the nature of the environmental factors that lead to analgesia with those that produce hyperalgesia.

Methodological refinements to the mouse paw formalin test. An animal model of tonic pain.

Evolutionary and comparative aspects of nociception

The relevance of animal neuropathy models for chronic pain in humans

There are currently more than 30 animal models for neuropathic pain. These models are characterized by specific combinations of anomalous nocifensive behavior which suggest the presence of

Biological rhythms in pain and in the effects of opioid analgesics.

For Debate: Reflex responses do not necessarily signify pain

Can a fetus feel pain? This question is appropriate, as medical interventions during pregnancy,1 fetal surgery,2 and possibly termination of pregnancy expose the fetus to noxious stimuli. To answer

A CRITIQUE OF ANALGESIC TESTING METHODS

  • L. C. Miller
  • Medicine
    Annals of the New York Academy of Sciences
  • 1948
TLDR
The literature on methods used up to that time to evaluatc pain intensity and the analgesic effects of drugs are reviewed, setting up four criteria which the ideal method should meet in yielding quantitative data on the extent to which an analgesic obtunds pain.

A behavioural model for the study of facial nociception and the effects of descending modulatory systems in the rat

...