Animal models of intra-oral chemical carcinogenesis: a review.

  title={Animal models of intra-oral chemical carcinogenesis: a review.},
  author={John W. Eveson},
  journal={Journal of oral pathology},
  volume={10 3},
Early attempts to induce malignant oral tumours were largely unsuccessful, as the oral mucosa is considerably more resistant to the actions of chemical carcinogens than skin. The first consistent success came when strong carcinogens were applied to the hamster cheek pouch. This model remains the most popular for studies of intra-oral carcinogenesis and is discussed at length. The advantages and disadvantages are critically reviewed. The models of intra-oral carcinogenesis in extra-pouch sites… CONTINUE READING
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