Animal models of human type 1 diabetes for evaluating combination therapies and successful translation to the patient with type 1 diabetes

@article{Lenzen2017AnimalMO,
  title={Animal models of human type 1 diabetes for evaluating combination therapies and successful translation to the patient with type 1 diabetes},
  author={Sigurd Lenzen},
  journal={Diabetes/Metabolism Research and Reviews},
  year={2017},
  volume={33}
}
  • S. Lenzen
  • Published 2017
  • Medicine
  • Diabetes/Metabolism Research and Reviews
Animal models of human type 1 diabetes will be of a great importance for the evaluation of new combination therapies with curative potential. However, reliable predictive power for successful translation to patients with type 1 diabetes is crucial. This will be particularly important in the future when evaluating success of new combination therapies that show great promise for preservation and restoration of beta cell mass and thereby reverse the type 1 diabetic hyperglycaemia. But not all… Expand
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References

SHOWING 1-10 OF 39 REFERENCES
The use of animal models in diabetes research
  • A. King
  • Medicine
  • British journal of pharmacology
  • 2012
TLDR
Some of the models currently used in diabetes research are outlined, including transgenic and knock‐out mouse models, which range from animals with spontaneously developing autoimmune diabetes to chemical ablation of the pancreatic beta cells. Expand
Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes
TLDR
A combination of approved drugs demonstrates a novel ability to reverse T1D, thereby warranting translational consideration and allowing for effective treatment at reduced drug doses, thereby minimizing potential adverse effects while retaining efficacy. Expand
Are Insights Gained from NOD Mice Sufficient to Guide Clinical Translation?
  • B. Roep
  • Medicine
  • Annals of the New York Academy of Sciences
  • 2007
TLDR
It is argued that animal models have limited but evident value when it comes to teaching us about type 1 diabetes in humans, and the authors can take advantage of this value more efficiently. Expand
Experimental Diabetes Mellitus in Different Animal Models
TLDR
The pathophysiological features of diabetes in relation to its complications in type 1 and type 2 mice along with rat models are overviewed along with the challenges associated with the evaluation and predictive validation of these models as ideal animal models for preclinical assessments and discovering new drugs and therapeutic agents for translational application in humans. Expand
Combination therapy for preservation of beta cell function in Type 1 diabetes: new attitudes and strategies are needed!
TLDR
Treatment of Type 1 diabetes has certainly improved but too slowly and there is already evidence enough for intervention trials where immune suppression is combined with antigen treatment, beta cell protection, anti-inflammatory treatment, and efforts to stimulate beta cell regeneration. Expand
Rat models of type 1 diabetes: genetics, environment, and autoimmunity.
TLDR
Data generated in the rat have correctly predicted the outcome of several human diabetes prevention trials, notably the failure of nicotinamide and low dose parenteral and oral insulin therapies. Expand
Combination immunotherapies for type 1 diabetes mellitus
TLDR
Novel promising combination therapies are being developed, including those that couple immunomodulators with drugs that stimulate β-cell regeneration in order to restore normoglycaemia, an encouraging one to pursue the goal of finding a cure for T1DM. Expand
Immunotherapy of type 1 diabetes--how to rationally prioritize combination therapies in T1D.
TLDR
Promising monotherapeutic approaches are discussed, current clinical trials are summarized, and a rationale on how to prioritize different combinations of treatments is proposed. Expand
The NOD mouse model of type 1 diabetes: As good as it gets?
TLDR
The authors re-examine the value of this mouse model as a tool for understanding human diabetes and for testing potential therapies, reviewing both strengths and weaknesses. Expand
Developing combination immunotherapies for type 1 diabetes: recommendations from the ITN–JDRF Type 1 Diabetes Combination Therapy Assessment Group
TLDR
A Type 1 Diabetes Combination Therapy Assessment Group was convened and the recommendations, the recommendations of which are discussed in this Perspective paper, are discussed. Expand
...
1
2
3
4
...