Animal models of human disease: zebrafish swim into view

@article{Lieschke2007AnimalMO,
  title={Animal models of human disease: zebrafish swim into view},
  author={Graham J. Lieschke and Peter David Currie},
  journal={Nature Reviews Genetics},
  year={2007},
  volume={8},
  pages={353-367}
}
Despite the pre-eminence of the mouse in modelling human disease, several aspects of murine biology limit its routine use in large-scale genetic and therapeutic screening. Many researchers who are interested in an embryologically and genetically tractable disease model have now turned to zebrafish. Zebrafish biology allows ready access to all developmental stages, and the optical clarity of embryos and larvae allow real-time imaging of developing pathologies. Sophisticated mutagenesis and… CONTINUE READING
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