Animal models of depression: navigating through the clinical fog

  title={Animal models of depression: navigating through the clinical fog},
  author={Keith Matthews and David M. Christmas and John Swan and Eleanor Sorrell},
  journal={Neuroscience \& Biobehavioral Reviews},
Animal models of depression in drug discovery: A historical perspective
Animal models of mood disorders: recent developments
Endophenotype-based modelling of depression and bipolar illness is opening up more tractable avenues for understanding the neurobiological and genetic bases of these disorders and promises to yield better translational animal models and hence more fruitful therapeutic targets.
Behavioural Assays to Model Cognitive and Affective Dimensions of Depression and Anxiety in Rats
In preclinical investigations of the neural regulatory mechanisms linking stress to depression and anxiety disorders, as well as the mechanisms by which chronic treatment with antidepressant drugs may exert their beneficial effects in these conditions, a number of behavioural tests in rats are employed to model specific cognitive and anxiety‐like components of depression and Anxiety disorders.
Experimental animal models for the simulation of depression and anxiety
A pragmatic approach of combined preclinical and clinical efforts is necessary to imitate one or more aspects relevant to pathological anxiety disorders and depression, which may identify central nervous processes regulating defined behavioral output and the potential to develop more effective treatments.
Model organisms: The ascent of mouse: advances in modelling human depression and anxiety
The current status of research into developing appropriate tests for assessing depression- and anxiety-related behaviours in mice is assessed.
Animal models of major depression and their clinical implications
Pathogenesis of depression: Insights from human and rodent studies
Animal Models of Depression
This chapter reviews several depression assays involving acute stress, models consisting of prolonged physical or socialstress, models of secondary depression, genetic models, and experiments designed to elucidate the mechanisms of antidepressant action.
The Utility of Animal Models in Understanding Links between Psychosocial Processes and Cardiovascular Health.
  • A. Grippo
  • Psychology, Biology
    Social and personality psychology compass
  • 2011
The study of mechanisms underlying mood and cardiovascular regulation using animal models will enhance the understanding of the association of depression and cardiovascular disease, and can promote the development of novel interventions for individuals with these comorbid conditions.


Animal Models of Depression in Neuropsychopharmacology qua Feyerabendian Philosophy of Science
The neuropsychopharmacological methods and theories used to investigate the nature of depression have been viewed as suspect for a variety of philosophical and scientific reasons. Much of this
Treatment-resistant depression.
Clinical studies investigating the predictors of resistance following the failure of 2 or more antidepressant trials should be pursued, and further controlled clinical trials are essential to identify the most effective treatment strategies.
Randomised controlled trials investigating pharmacological and psychological interventions for treatment-refractory depression
There is little evidence to guide the management of depression that has not responded to a course of antidepressants, and large pragmatic trials are needed to inform clinical practice.
Are subjects in pharmacological treatment trials of depression representative of patients in routine clinical practice?
Results show that antidepressant efficacy trials tend to evaluate a subset of depressed individuals with a specific clinical profile, and subjects treated in antidepressant trials represent a minority of patients treated for major depression in routine clinical practice.
The validity of animal models of depression
  • P. Willner
  • Psychology, Biology
  • 2004
The models with the highest overall validity are the intracranial self-stimulation, chronic stress and learned helplessness models in rats, and the primate separation model.
Neurocognitive impairment in drug-free patients with major depressive disorder
Pronounced neurocognitive impairment was found in this sample of young adult out-patients with MDD, and could therefore provide an objective marker of brain dysfunction in depression.
National Institute of Mental Health Treatment of Depression Collaborative Research Program. General effectiveness of treatments.
There was limited evidence of the specific effectiveness of interpersonal psychotherapy and none for cognitive behavior therapy, but Superior recovery rates were found for both interpersonal Psychotherapy and imipramine plusclinical management, as compared with placebo plus clinical management.
Subgenual prefrontal cortex abnormalities in mood disorders
Using positron emission tomographic images of cerebral blood flow and rate of glucose metabolism to measure brain activity, an area of abnormally decreased activity is localized in the pre-frontal cortex ventral to the genu of the corpus callosum in both familial bipolar depressives and familial unipolar depressives.
Differential brain metabolic predictors of response to paroxetine in obsessive-compulsive disorder versus major depression.
Findings suggest that, although both OCD and major depressive disorder respond to SRIs, the two syndromes have different neurobiological substrates for response.