Animal models of depression: navigating through the clinical fog

@article{Matthews2005AnimalMO,
  title={Animal models of depression: navigating through the clinical fog},
  author={K. Matthews and D. Christmas and J. Swan and Eleanor Sorrell},
  journal={Neuroscience \& Biobehavioral Reviews},
  year={2005},
  volume={29},
  pages={503-513}
}
Animal models of human disease have proven of considerable value in elucidating basic pathophysiological mechanisms and in developing novel treatments. However, modelling human mental disorders in experimental animals is fraught with difficulties. Depression models generally lack both clinical and scientific credibility and have, thus far, failed to inform treatment strategies previously acquired through serendipity. The complexity and heterogeneity of the clinical states labelled 'depression… Expand
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