Animal models of cigarette smoke-induced COPD.

@article{Wright2002AnimalMO,
  title={Animal models of cigarette smoke-induced COPD.},
  author={Joanne Lynne Wright and Andrew M. Churg},
  journal={Chest},
  year={2002},
  volume={122 6 Suppl},
  pages={
          301S-306S
        }
}
OBJECTIVES To review the animal models of COPD, and to compare these data to those found in humans. RESULTS Smoke-induced animal models can produce emphysema, although the lesions are not generally close mimics of human emphysema, as well as increases in mucous-secreting cells and vascular changes including pulmonary hypertension. There is considerable species-to-species variation in the degree and/or presence of these different abnormalities, so that care has to be used in selecting a… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 51 REFERENCES

The importance of ultramicroscopic emphysema in cigarette smoke induced lung disease

  • JL Wright
  • Lung
  • 2001

Subepithelial immuno - pathology of the large airways in smokers with and without chronic obstructive pulmonary disease

  • Lams BEA, AR Sousa, PJ Rees
  • Eur Respir J
  • 2000

Cigarette smoke exposure produces more evidence of emphysema in BGC 3 F 1 mice than in F 344 rats

  • TH March, EB Barr, GL Finch
  • Toxicol Sci
  • 1999

Immunopathology of the small - airway submucosa in smokers with and without chronic obstructive pulmonary disease

  • Lams BEA, AR Sousa, PJ Rees
  • Am J Respir Crit Care Med
  • 1999