Animal models of cigarette smoke-induced COPD.

@article{Wright2002AnimalMO,
  title={Animal models of cigarette smoke-induced COPD.},
  author={Joanne Lynne Wright and Andrew Churg},
  journal={Chest},
  year={2002},
  volume={122 6 Suppl},
  pages={
          301S-306S
        }
}
OBJECTIVES To review the animal models of COPD, and to compare these data to those found in humans. RESULTS Smoke-induced animal models can produce emphysema, although the lesions are not generally close mimics of human emphysema, as well as increases in mucous-secreting cells and vascular changes including pulmonary hypertension. There is considerable species-to-species variation in the degree and/or presence of these different abnormalities, so that care has to be used in selecting a… Expand
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