Animal models of brain maldevelopment induced by cycad plant genotoxins.

  title={Animal models of brain maldevelopment induced by cycad plant genotoxins.},
  author={Glen E. Kisby and Holly Ann Moore and Peter S. Spencer},
  journal={Birth defects research. Part C, Embryo today : reviews},
  volume={99 4},
Cycads are long-lived tropical and subtropical plants that contain azoxyglycosides (e.g., cycasin, macrozamin) and neurotoxic amino acids (notably β-N-methylamino-l-alanine l-BMAA), toxins that have been implicated in the etiology of a disappearing neurodegenerative disease, amyotrophic lateral sclerosis and parkinsonism-dementia complex that has been present in high incidence among three genetically distinct populations in the western Pacific. The neuropathology of amyotrophic lateral… CONTINUE READING
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