Animal models of biliary injury and altered bile acid metabolism.

  title={Animal models of biliary injury and altered bile acid metabolism.},
  author={Valeria Mariotti and Mario Strazzabosco and Luca Fabris and Diego F Calvisi},
  journal={Biochimica et biophysica acta. Molecular basis of disease},
  volume={1864 4 Pt B},
In the last 25years, a number of animal models, mainly rodents, have been generated with the goal to mimic cholestatic liver injuries and, thus, to provide in vivo tools to investigate the mechanisms of biliary repair and, eventually, to test the efficacy of innovative treatments. Despite fundamental limitations applying to these models, such as the distinct immune system and the different metabolism regulating liver homeostasis in rodents when compared to humans, multiple approaches, such as… CONTINUE READING
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