Animal models of aging research: implications for human aging and age-related diseases.

  title={Animal models of aging research: implications for human aging and age-related diseases.},
  author={Sarah Jayne Mitchell and Morten Scheibye-Knudsen and D. Longo and Rafael de Cabo},
  journal={Annual review of animal biosciences},
Aging is characterized by an increasing morbidity and functional decline that eventually results in the death of an organism. Aging is the largest risk factor for numerous human diseases, and understanding the aging process may thereby facilitate the development of new treatments for age-associated diseases. The use of humans in aging research is complicated by many factors, including ethical issues; environmental and social factors; and perhaps most importantly, their long natural life span… 

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