Animal models in the study of the unfolded protein response.


The endoplasmic reticulum, a highly dynamic and complex organelle, is the site for synthesis, folding, and modification of transmembrane and secretory proteins. Any disruptions to the endoplasmic reticulum such as an accumulation of misfolded or unfolded proteins results in activation of the unfolded protein response (UPR). The UPR is comprised of three… (More)
DOI: 10.1016/B978-0-12-385928-0.00006-7


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