Animal models have little to teach us about Type 1 diabetes: 2. In opposition to this proposal

@article{Leiter2004AnimalMH,
  title={Animal models have little to teach us about Type 1 diabetes: 2. In opposition to this proposal},
  author={Edward H. Leiter and Matthias von G. Herrath},
  journal={Diabetologia},
  year={2004},
  volume={47},
  pages={1657-1660}
}
that animal models in general, and rodent models of Type 1 diabetes in particular, are imperfect reflections of human disease [1]. This is the inevitable consequence of an evolutionary separation of over 65 million years. While pointing out the numerous differences that distinguish human from rodent immune systems, Mestas and Hughes [2] note that “after all, most of us do not live with our noses a half-inch off the ground.” Clearly, divergent evolution in genera occupying different niches… CONTINUE READING
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