Animal models for the comparative assessment of neurotoxicity following repeated administration of vinca alkaloids.

@article{Todd1979AnimalMF,
  title={Animal models for the comparative assessment of neurotoxicity following repeated administration of vinca alkaloids.},
  author={Gordon Todd and W. J. Griffing and W. R. Gibson and Douglas M. Morton},
  journal={Cancer treatment reports},
  year={1979},
  volume={63 1},
  pages={
          35-41
        }
}
Neurotoxicity is the major side effect occurring during the clinical use of vincristine (VCR). Animal models predictive of potential neurotoxicity would be very useful in the preclinical development of new vinca compounds. To simulate conditions in which neurotoxicity is produced during the clinical use of VCR, experimental animals (except the guinea pig) were given the test compounds by the iv route over a prolonged time period. Doses were selected based on the production of leukopenia… CONTINUE READING

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