Animal models for tardive dyskinesia: effects of thioridazine.

  title={Animal models for tardive dyskinesia: effects of thioridazine.},
  author={Anthony C. Sayers and Hans R. B{\"u}rki and Walter Ruch and Helmuth Asper},
  journal={Pharmakopsychiatrie, Neuro-Psychopharmakologie},
  volume={10 5},
After repeated administration of classical neuroloptics to the rat, supersensitivity of striatal dopamine (DA) receptors towards DA-receptor agonists can be demonstrated. This effect can be quantified (a) by measuring the turning response to apomorphine in rats with unilateral striatal lesions or (b) by measuring the changes induced by neuroleptics in the DA metabolism in the striatum of intact rats. In these test systems, thioridazine induces an increase in DA-receptor sensitivity which is… CONTINUE READING