Animal models for skin blistering conditions: absence of laminin 5 causes hereditary junctional mechanobullous disease in the Belgian horse.

@article{Spirito2002AnimalMF,
  title={Animal models for skin blistering conditions: absence of laminin 5 causes hereditary junctional mechanobullous disease in the Belgian horse.},
  author={Flavia Spirito and Alexandra V Charlesworth and Keith Linder and J -P Ortonne and John Baird and Guerrino Meneguzzi},
  journal={The Journal of investigative dermatology},
  year={2002},
  volume={119 3},
  pages={684-91}
}
Recent achievements in the genetic correction of keratinocytes isolated from patients with junctional epidermolysis bullosa have paved the way to a gene therapy approach for the disease. Because gene therapy protocols require preclinical validation in animals, we have characterized spontaneous animal models of junctional epidermolysis bullosa. In this study we have elucidated the genetic basis of the hereditary junctional mechanobullous disease in the Belgian horse, a condition characterized by… CONTINUE READING
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