Animal models for benign prostatic hyperplasia.

  title={Animal models for benign prostatic hyperplasia.},
  author={J. Paul Hieble},
  journal={Handbook of experimental pharmacology},
Although the etiology of benign prostatic hyperplasia (BPH) is unknown, various animal models have been used for several decades to identify potential therapeutic approaches. These models can be divided into those measuring smooth muscle tone and those measuring cellular proliferation. Animal models have played an important role in the development of the two drug classes currently approved for the treatment of BPH: the α-adrenoceptor antagonists and the steroid 5-α-reductase inhibitors. However… CONTINUE READING