Animal models and their importance to human physiological responses in microgravity.

@article{Tipton1996AnimalMA,
  title={Animal models and their importance to human physiological responses in microgravity.},
  author={Charles M. Tipton},
  journal={Medicine and science in sports and exercise},
  year={1996},
  volume={28 10 Suppl},
  pages={S94-100}
}
Two prominent theories to explain the physiological effects of microgravity relate to the cascade of changes associated with the cephalic shifts of fluids and the absence of tissue deformation forces. One-g experiments for humans used bed rest and the head-down tilt (HDT) method, while animal experiments have been conducted using the tail-suspended, head-down, and hindlimbs non-weightbearing model. Because of the success of the HDT approach with rats to simulate the gravitational effects on the… CONTINUE READING

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Results to date indicate the model is effective in producing comparable changes associated with blood volume , erythropoiesis , cardiac mass , baroreceptor responsiveness , carbohydrate metabolism , post - flight VO2max , and post - flight cardiac output during exercise .
Results to date indicate the model is effective in producing comparable changes associated with blood volume , erythropoiesis , cardiac mass , baroreceptor responsiveness , carbohydrate metabolism , post - flight VO2max , and post - flight cardiac output during exercise .
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