Animal modeling an oligodendrogliopathy – multiple system atrophy

  title={Animal modeling an oligodendrogliopathy – multiple system atrophy},
  author={Jonathan M. Bleasel and Glenda M Halliday and Woojin Kim},
  booktitle={Acta neuropathologica communications},
Multiple system atrophy (MSA) is a rare, yet rapidly-progressive neurodegenerative disease that presents clinically with autonomic failure in combination with parkinsonism or cerebellar ataxia. The definitive neuropathology differentiating MSA from Lewy body diseases is the presence of α-synuclein aggregates in oligodendrocytes (called glial cytoplasmic inclusion or GCI) rather than the fibrillar aggregates in neurons (called Lewy bodies). This makes the pathological pathway(s) in MSA unique in… CONTINUE READING
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α-Synuclein is phosphorylated in synucleinopathy lesions

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