Animal model of schizophrenia: dysfunction of NMDA receptor-signaling in mice following withdrawal from repeated administration of phencyclidine.

@article{Nabeshima2006AnimalMO,
  title={Animal model of schizophrenia: dysfunction of NMDA receptor-signaling in mice following withdrawal from repeated administration of phencyclidine.},
  author={Toshitaka Nabeshima and Akihiro Mouri and Rina Murai and Yukihiro Noda},
  journal={Annals of the New York Academy of Sciences},
  year={2006},
  volume={1086},
  pages={160-8}
}
In humans, phencyclidine (PCP), a noncompetitive N-methyl-d-aspartate (NMDA) antagonist, reproduces a schizophrenia-like psychosis such as positive/negative symptoms and cognitive deficits. PCP (10 mg/kg/day for 14 days)-treated mice exhibit the enhanced immobility in a forced swimming test as indexes of negative symptoms and impairment of latent learning in a water finding test as indexes of cognitive deficits. These behavioral deficits remain after withdrawal from repeated PCP treatment and… CONTINUE READING

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