Animal model of cerebral aneurysms: pathology and pathogenesis of induced cerebral aneurysms in rats.

@article{Hashimoto1984AnimalMO,
  title={Animal model of cerebral aneurysms: pathology and pathogenesis of induced cerebral aneurysms in rats.},
  author={Naomi Hashimoto and Hajime Handa and Izumi Nagata and Fumitada Hazama},
  journal={Neurological research},
  year={1984},
  volume={6 1-2},
  pages={33-40}
}
Saccular cerebral aneurysms are induced in rats treated with ligation of one or both of the common carotid arteries, experimental hypertension, and beta-aminopropionitrile feeding. Combination of ligation of the carotid artery and experimental hypertension is the minimal requirement for inducing aneurysms within a few months. beta-aminopropionitrile makes the arterial wall fragile, increasing the incidence of aneurysmal development. Induced aneurysms are strongly related to haemodynamic… CONTINUE READING

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