Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes.

@article{Garesse2001AnimalMB,
  title={Animal mitochondrial biogenesis and function: a regulatory cross-talk between two genomes.},
  author={Rafael Garesse and Carmen G. Vallejo},
  journal={Gene},
  year={2001},
  volume={263 1-2},
  pages={1-16}
}
Mitochondria play a pivotal role in cell physiology, producing the cellular energy and other essential metabolites as well as controlling apoptosis by integrating numerous death signals. The biogenesis of the oxidative phosphorylation system (OXPHOS) depends on the coordinated expression of two genomes, nuclear and mitochondrial. As a consequence, the control of mitochondrial biogenesis and function depends on extremely complex processes that require a variety of well orchestrated regulatory… CONTINUE READING

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