Animal Transmissible Spongiform Encephalopathies and Genetics

  title={Animal Transmissible Spongiform Encephalopathies and Genetics},
  author={Umberto Agrimi and Michela Conte and Luisella Morelli and Michele A. Di Bari and Giovanni Di Guardo and Ciriaco Ligios and Giovanni Antonucci and G. M. Aufiero and Nicola Pozzato and Franco Mutinelli and Romolo Nonno and Gabriele Vaccari},
  journal={Veterinary Research Communications},
The genotype of the host plays a crucial role in the pathogenesis of transmissible spongiform encephalopathies (TSEs). In this respect, the most important factor is represented by the gene of the prion protein (PrP). The present work summarizes the currently available knowledge on the genetic basis of TSEs focusing, in particular, on sheep scrapie. Interest in this disease has grown markedly following the discovery of bovine spongiform encephalopathy, both for scientific and health reasons. In… CONTINUE READING
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