Animal Models to Detect Antidepressants

  title={Animal Models to Detect Antidepressants},
  author={Paul Willner and Mariusz Papp},
Rational strategies for the development of novel antidepressant agents are based on an analysis of perceived therapeutic needs, which in turn derive from the inadequacies of the therapies that are currently available. The traditional (first-generation) antidepressants suffer from three major drawbacks: They have unacceptable side effects; their efficacy is low; and their therapeutic effects develop slowly, typically requiring 3–4 wk of treatment before clear improvements in mood are apparent… CONTINUE READING

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