Animal Models of Scleroderma: Current State and Recent Development

@article{Asano2013AnimalMO,
  title={Animal Models of Scleroderma: Current State and Recent Development},
  author={Yoshihide Asano and Shin-Ichi Sato},
  journal={Current Rheumatology Reports},
  year={2013},
  volume={15},
  pages={1-9}
}
Systemic sclerosis (SSc) is a multisystem connective tissue disease characterized by three cardinal features: immunological abnormalities, vasculopathy, and fibrosis of skin and certain internal organs. Although several animal models recapitulating selected aspects of SSc have been reported, the absence of models fulfilling the full clinical picture of SSc has hindered progress in the development and testing of therapy for this disease. In recent years, three new inducible animal models have… CONTINUE READING
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