Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis

  title={Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis},
  author={Erin Teeple and Gregory D. Jay and Khaled A Elsaid and Braden C. Fleming},
  journal={The AAPS Journal},
Osteoarthritis (OA) is the most common musculoskeletal disease, affecting millions of individuals worldwide. New treatment approaches require an understanding of the pathophysiology of OA and its biomechanical, inflammatory, genetic, and environmental risk factors. The purpose of animal models of OA is to reproduce the pattern and progression of degenerative damage in a controlled fashion, so that opportunities to monitor and modulate symptoms and disease progression can be identified and new… CONTINUE READING

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Publications referenced by this paper.
Showing 1-10 of 53 references

Probing articular cartilage damage and disease by quantitative magnetic resonance imaging.

Journal of the Royal Society, Interface • 2013
View 6 Excerpts
Highly Influenced

Osteoarthritis and cartilage/OARS, Osteoarthritis

T Aigner, S Lohmander, editors
OAC Histopathology Supplement • 2010
View 5 Excerpts
Highly Influenced

Animal models of osteoarthritis.

Journal of musculoskeletal & neuronal interactions • 2001
View 3 Excerpts
Highly Influenced

A collagen platelet composite to stimulate healing after ACL surgery also minimizes cartilage damage in the ACL injured knee

BC Fleming, MT Machan, MT Shalvoy, MM. Murray
Osteoarthritis Cartilage • 2012
View 1 Excerpt

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