Animal Models of Entamoeba histolytica Infection

@inproceedings{Stanley1999AnimalMO,
  title={Animal Models of Entamoeba histolytica Infection},
  author={S. Stanley and Tonghai Zhang and K. Seydel},
  year={1999}
}
Publisher Summary This chapter presents animal models of Entamoeba histolytica infection. Male or female CB-17 SCID mice, aged 6–10 weeks old, are used as xenograft recipients. Since maturation of the intestinal xenograft requires at least 10 weeks post-surgery, use of younger mice are recommended. All SCID mice are screened for the "leaky" phenotype at the age of five weeks by measuring serum antibodies by using an enzyme-linked immunosorbent (ELISA) assay. SCID mice are housed in a sterile… Expand
2 Citations
Expression of Amoebapores Is Required for Full Expression of Entamoeba histolytica Virulence in Amebic Liver Abscess but Is Not Necessary for the Induction of Inflammation or Tissue Damage in Amebic Colitis
TLDR
It is demonstrated that amoebapore expression is required for full virulence in the SCID mouse model of amebic liver abscess, but E. histolytica trophozoites that do not express amoEBapore-A can still cause inflammation and tissue damage in infected human colonic xenografts. Expand
Water-Soluble Ruthenium (II) Chiral Heteroleptic Complexes with Amoebicidal in Vitro and in Vivo Activity.
TLDR
Three water-soluble Ru(II) chiral heteroleptic coordination compounds inhibit the trophozoite proliferation in amoebic liver abscess induced in hamster, and are proposed as promising candidates as antiparasitic agents. Expand

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